Scripted producer Sister is to close its US office and put all of its focus on its UK business from the end of the year.
The decision affects 20 US-based staff, with global chief executive Cindy Holland stepping down after just over 15 months in the role.
Chief financial officer Chris Fry will act as interim chief executive while Sister recruits for her replacement.
While Sister will retain its US investments such as Dorothy St Pictures and podcast company Campside Media, it will no longer have an LA base and will produce all of its output out of the UK.
Sister's US productions included Dan Levy's Netflix film Good Grief.
While Netflix cancelled Sister’s high-profile drama Kaos [main picture] after just one series, the indie’s upcoming series for the streamer, Black Doves, has already been recommissioned before series one’s release.
“These are challenging times for production companies, requiring difficult decisions,” said Murdoch.
“The Board believes, as I do, that we can significantly boost sustainable growth and strengthen our group by doubling down on our proven track record of successfully producing from the UK for a worldwide audience.
“Our exceptional UK base for Sister film and television operations that sells and produces for the US and the world will be our model moving forward. I’m thankful for the work of the Sister US film and television team, and we will take care of them.”